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Structural basis of nucleotide sugar transport across the Golgi membrane

Abstract:

Glycosylation is a fundamental cellular process that, in eukaryotes, occurs in the lumen of both the Golgi apparatus and the endoplasmic reticulum1. Nucleotide sugar transporters (NSTs) are an essential component of the glycosylation pathway, providing the diverse range of substrates required for the glycosyltransferases2,3. NSTs are linked to several developmental and immune disorders in humans, and in pathogenic microbes they have an important role in virulence4,5,6,7,8. How NSTs recognize ...

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Publication status:
Published

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Publisher copy:
10.1038/nature24464

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
Christ Church
ORCID:
0000-0001-7432-2270
Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
551
Issue:
7681
Pages:
521-524
Publication date:
2017-11-15
Acceptance date:
2017-09-27
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pubs id:
pubs:803120
URN:
uri:52d171bc-7ef6-498d-ad29-16fed05f0871
UUID:
uuid:52d171bc-7ef6-498d-ad29-16fed05f0871
Local pid:
pubs:803120

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