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Thesis

Autophagy-dependent generation of free fatty acids is essential for normal neutrophil differentiation by guiding an energy-metabolic switch

Abstract:

Neutrophils are critical and short lived mediators of innate immunity that require constant replenishment. Their differentiation in the bone marrow requires extensive cytoplasmic and nuclear remodeling, but the processes governing these energy-consuming changes are unknown. While previous studies show that autophagy is required for differentiation of other blood cell lineages, its function during granulopoiesis has remained elusive. Autophagy was described as a critical process in HSC diff...

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Division:
MSD
Department:
RDM
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:52c98f4d-c2a0-43b0-be5b-91e51d52d966
Deposit date:
2018-02-13

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