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Journal article

Identification of a bifunctional lipopolysaccharide sialyltransferase in Haemophilus influenzae: incorporation of disialic acid.

Abstract:

The lipopolysaccharide (LPS) of non-typeable Haemophilus influenzae (NTHi) can be substituted at various positions by N-acetylneuraminic acid (Neu5Ac). LPS sialylation plays an important role in pathogenesis. The only LPS sialyltransferase characterized biochemically to date in H. influenzae is Lic3A, an alpha-2,3-sialyltransferase responsible for the addition of Neu5Ac to a lactose acceptor (Hood, D. W., Cox, A. D., Gilbert, M., Makepeace, K., Walsh, S., Deadman, M. E., Cody, A., Martin, A.,...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m602314200

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Journal:
The Journal of biological chemistry
Volume:
281
Issue:
52
Pages:
40024-40032
Publication date:
2006-12-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:52c9397c-44e0-4adc-afcc-f8ba6429baf9
Source identifiers:
115597
Local pid:
pubs:115597

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