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Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers.

Abstract:

Mutations in the BRCA1 gene substantially increase a woman's lifetime risk of breast cancer. However, there is great variation in this increase in risk with several genetic and non-genetic modifiers identified. The BRCA1 protein plays a central role in DNA repair, a mechanism that is particularly instrumental in safeguarding cells against tumorigenesis. We hypothesized that polymorphisms that alter the expression and/or function of BRCA1 carried on the wild-type (non-mutated) copy of the BRCA...

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Publisher copy:
10.1093/hmg/ddr388

Authors


Sinnett, D More by this author
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Journal:
Human molecular genetics
Volume:
20
Issue:
23
Pages:
4732-4747
Publication date:
2011-12-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:52b7bc01-589c-4f01-8776-4f79ab8b3872
Source identifiers:
216359
Local pid:
pubs:216359

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