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A protein-protein interaction map of the Trypanosoma brucei paraflagellar rod.

Abstract:

We have conducted a protein interaction study of components within a specific sub-compartment of a eukaryotic flagellum. The trypanosome flagellum contains a para-crystalline extra-axonemal structure termed the paraflagellar rod (PFR) with around forty identified components. We have used a Gateway cloning approach coupled with yeast two-hybrid, RNAi and 2D DiGE to define a protein-protein interaction network taking place in this structure. We define two clusters of interactions; the first bei...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0007685

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Funding agency for:
Gull, K
Wellcome Trust More from this funder
Human Frontier Science Program More from this funder
EP Abraham Trust More from this funder
Engineering and Physical Sciences Research Council More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
4
Issue:
11
Pages:
Article: e7685
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:52adbf5a-5089-4afe-b630-d69ae1bf7f03
Source identifiers:
20418
Local pid:
pubs:20418

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