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Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors.

Abstract:

It has been established that 5-HT(1A) receptors are expressed both presynaptically as autoreceptors by 5-HT containing neurones, and postsynaptically by a variety of other neurones. Activation of either somatodendritic 5-HT(1A) autoreceptors or postsynaptic 5-HT(1A) receptors induces hyperpolarisation and inhibition of action potential discharge of the neurones, but it is unclear whether 5-HT(1A) receptors are under a general tonic influence by 5-HT. In the present study, using single unit re...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Journal:
Neuroscience letters
Volume:
304
Issue:
3
Pages:
129-132
Publication date:
2001-05-05
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
URN:
uuid:52a98996-0e1d-473d-ae1f-eeae356234ad
Source identifiers:
185257
Local pid:
pubs:185257

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