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The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis.

Abstract:

Neurochemical biomarkers are urgently sought in ALS. Metabolomic analysis of cerebrospinal fluid (CSF) using proton nuclear magnetic resonance ((1)H-NMR) spectroscopy is a highly sensitive method capable of revealing nervous system cellular pathology. The (1)H-NMR CSF metabolomic signature of ALS was sought in a longitudinal cohort. Six-monthly serial collection was performed in ALS patients across a range of clinical sub-types (n = 41) for up to two years, and in healthy controls at a single...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3109/21678421.2015.1053490

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst For Radiation Oncology
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Thierry Latran Foundation More from this funder
Publisher:
Taylor and Francis Publisher's website
Journal:
Amyotrophic lateral sclerosis and frontotemporal degeneration Journal website
Volume:
16
Issue:
7-8
Pages:
456-463
Publication date:
2015-12-22
DOI:
EISSN:
2167-9223
ISSN:
2167-8421
URN:
uuid:52a90ce3-07c1-4b83-ac3d-f340928754fa
Source identifiers:
529175
Local pid:
pubs:529175

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