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Chronic administration of dimebon ameliorates pathology in TauP301S transgenic mice.

Abstract:

Dimebon belongs to a fast-growing group of "old" drugs that were suggested to be effective for therapy of pathological conditions different from their original targets. Following initial reports of successful Phase II clinical trials for mild-to-moderate Alzheimer's and Huntington's diseases, effects of Dimebon on various neurodegenerative conditions were investigated both in follow-up clinical trials and in various model systems. Although results of Phase III clinical trials carried out so f...

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Publisher copy:
10.3233/jad-2012-121732

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Journal:
Journal of Alzheimer's disease : JAD
Volume:
33
Issue:
4
Pages:
1041-1049
Publication date:
2013-01-01
DOI:
EISSN:
1875-8908
ISSN:
1387-2877
URN:
uuid:529e9be4-0339-4fdf-99ae-9890ab2b4ec8
Source identifiers:
492371
Local pid:
pubs:492371

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