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Genetic and epigenetic studies of adiposity and cardiometabolic disease.

Abstract:
Over 300 million adults are obese, but little is known about the impact of obesity on cardiovascular health. We discuss recent genetic and epigenetic studies of adiposity that indicate a causal role for general and central adiposity in cardiometabolic disease, and highlight potential mechanisms including insulin resistance and gene expression.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13073-017-0474-5

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Big Data Institute
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Big Data Institute
National Institute for Health Research More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Genome medicine Journal website
Volume:
9
Issue:
82
Pages:
1-4
Publication date:
2017-09-18
Acceptance date:
2017-09-11
DOI:
ISSN:
1756-994X
Pubs id:
pubs:730049
URN:
uri:529cf961-6b23-48d0-89c1-75d561d774a3
UUID:
uuid:529cf961-6b23-48d0-89c1-75d561d774a3
Local pid:
pubs:730049

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