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Genetic determinants of serum testosterone concentrations in men.

Abstract:

Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testoste...

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10.1371/journal.pgen.1002313

Authors


Ohlsson, C More by this author
Wallaschofski, H More by this author
Lunetta, KL More by this author
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Journal:
PLoS genetics
Volume:
7
Issue:
10
Pages:
e1002313
Publication date:
2011-10-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:5290c72d-58eb-4220-8012-b9848db7f8b0
Source identifiers:
213649
Local pid:
pubs:213649

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