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Assessing treatment effect moderation in trials of psychological interventions: a case for individual participant data meta-analysis of pooled trials

Abstract:

The investigation of treatment effect moderation is a common research objective in psychological studies. The benefit or harm of an intervention might vary within a study according to patient characteristics or between studies due to contextual factors such as the composition of the study population or the study setting. Statistically the investigation of treatment effect moderation amounts to an assessment of interactions between putative moderators and treatment groups. Interaction tests te...

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Publication status:
Published
Peer review status:
Reviewed (Other)

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Publisher copy:
10.1186/s13063-017-1902-y

Authors


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Institution:
University of Oxford
Division:
Social Sciences Division
Department:
Social Policy & Intervention
Bonin, E-M More by this author
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Publisher:
BioMed Central Publisher's website
Journal:
4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials Journal website
Publication date:
2017-05-08
Acceptance date:
2016-12-22
DOI:
ISSN:
1745-6215
Pubs id:
pubs:735025
URN:
uri:5287b426-7474-4b20-ba4f-a99b1849f14e
UUID:
uuid:5287b426-7474-4b20-ba4f-a99b1849f14e
Local pid:
pubs:735025

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