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Highly immunogenic virally vectored T-cell vaccines cannot overcome subversion of the T-cell response by HCV during chronic infection

Abstract:

An effective therapeutic vaccine for the treatment of chronic hepatitis C virus (HCV) infection, as an adjunct to newly developed directly-acting antivirals (DAA), or for the prevention of reinfection would significantly reduce the global burden of disease associated with chronic HCV infection.

A recombinant chimpanzee adenoviral (ChAd3) vector and a modified vaccinia Ankara (MVA), encoding the non-structural proteins of HCV (NSmut), used in a heterologous prime/boost regimen induc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3390/vaccines4030027

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NIHR Oxford Biomedical Research Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NIHR Oxford Biomedical Research Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM
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Wellcome Trust More from this funder
Publisher:
MDPI Publisher's website
Journal:
Vaccines Journal website
Publication date:
2016-08-02
DOI:
ISSN:
2076-393X
URN:
uuid:5281d872-bdf3-44e4-baf0-c5f54c9e842c
Source identifiers:
634778
Local pid:
pubs:634778

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