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Construction of a human X-chromosome-enriched phage library which facilitates analysis of specific loci.

Abstract:

A human X-chromosome-enriched MboI-partial-digest recombinant library in phage lambda Charon30 has been constructed. Twelve out of the thirteen X-chromosome DNA sequences that were tested were present in the library. Most regions were covered in overlapping phage inserts; mean insert size was 13.7 kb. One phage from the library allowed detection of a 225-bp insertion of DNA into a region near the Duchenne muscular dystrophy (DMD) locus. Another recombinant phage represents an expansion of a r...

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Publication status:
Published

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Authors


Kunkel, LM More by this author
Lalande, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Middlesworth, W More by this author
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Journal:
Gene
Volume:
33
Issue:
3
Pages:
251-258
Publication date:
1985
DOI:
EISSN:
1879-0038
ISSN:
0378-1119
URN:
uuid:52715140-b360-45e5-b228-da3a387154dc
Source identifiers:
115674
Local pid:
pubs:115674

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