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Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia (ARREST): study protocol for a randomised controlled trial.

Abstract:

BACKGROUND: Staphylococcus aureus bacteraemia is a common and serious infection, with an associated mortality of ~25%. Once in the blood, S. aureus can disseminate to infect almost any organ, but bones, joints and heart valves are most frequently affected. Despite the infection's severity, the evidence guiding optimal antibiotic therapy is weak: fewer than 1,500 patients have been included in 16 randomised controlled trials investigating S. aureus bacteraemia treatment. It is uncertain which...

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Publication status:
Published

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Publisher copy:
10.1186/1745-6215-13-241

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
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Journal:
Trials
Volume:
13
Issue:
1
Pages:
241
Publication date:
2012-01-01
DOI:
EISSN:
1745-6215
ISSN:
1745-6215
URN:
uuid:526ba10d-e83a-4beb-b192-d6acb7b9c4bd
Source identifiers:
385007
Local pid:
pubs:385007

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