Journal article icon

Journal article

Convergent evolution and topologically disruptive polymorphisms among multidrug-resistant tuberculosis in Peru

Abstract:

Background

Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic and preventive strategies.

Methods

Here, we use novel genome-wide analysis techniques to identify polymorphisms that are associated with drug resistance, adaptive evolution and the structure of the phylogenetic tree. A total of 471 samples from...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0189838

Authors


Grandjean, L More by this author
Gilman, RH More by this author
Iwamoto, T More by this author
Köser, CU More by this author
Coronel, J More by this author
Expand authors...

Contributors

Role:
Editor
Department of Health More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
12
Pages:
e0189838
Publication date:
2017-12-05
Acceptance date:
2017-12-01
DOI:
EISSN:
1932-6203
Pubs id:
pubs:824059
URN:
uri:52679960-1aab-46cd-8efe-290615c19747
UUID:
uuid:52679960-1aab-46cd-8efe-290615c19747
Local pid:
pubs:824059

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP