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Thesis

Nuclear translation

Abstract:

In bacteria, protein synthesis can occur tightly coupled to transcription. In eukaryotes, it is believed that translation occurs solely in the cytoplasm; I test whether some occurs in nuclei and find: (1) L-azidohomoalanine (Aha) – a methionine analogue (detected by microscopy after attaching a fluorescent tag using ‘click’ chemistry) – is incorporated within 5 s into nuclei in a process sensitive to the translation inhibitor, anisomycin. (2) Puromycin – another inhibitor that end-labels n...

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Division:
MSD
Department:
Pathology Dunn School
Research group:
Nuclear Structure and Function Research Group
Oxford college:
Lincoln College
Role:
Author

Contributors

Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Supervisor
More from this funder
Name:
Felix Scholarship
Funding agency for:
Baboo, S
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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