Journal article icon

Journal article

Nonhomologous end-joining promotes resistance to DNA damage in the absence of an ADP-ribosyltransferase that signals DNA single strand breaks.

Abstract:

ADP-ribosylation of proteins at DNA lesions by ADP-ribosyltransferases (ARTs) is an early response to DNA damage. The best defined role of ADP-ribosylation in the DNA damage response is in repair of single strand breaks (SSBs). Recently, we initiated a study of how ADP-ribosylation regulates DNA repair in Dictyostelium and found that two ARTs (Adprt1b and Adprt2) are required for tolerance of cells to SSBs, and a third ART (Adprt1a) promotes nonhomologous end-joining (NHEJ). Here we report th...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1242/jcs.128769

Authors


Rakhimova, A More by this author
Lempidaki, S More by this author
Expand authors...
Journal:
Journal of cell science
Volume:
126
Issue:
Pt 15
Pages:
3452-3461
Publication date:
2013-08-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:5254775a-a205-4067-9145-56cdedf8e3e8
Source identifiers:
412182
Local pid:
pubs:412182

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP