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Journal article

Absence of co-stimulation and not the intensity of TCR signaling is critical for the induction of T cell unresponsiveness in vivo.

Abstract:

Understanding the mechanisms of T cell activation versus induction of unresponsiveness is of critical importance for the rational modulation of immune responses. Efficient T cell activation is critical for vaccination purposes, while the inhibition of T cell responses is potentially important for the ablation of autoimmune diseases. Modulation of co-stimulation and changing TCR-mediated signaling using altered peptide ligands (APL) have been shown to result in clonal T cell unresponsiveness. ...

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Publication status:
Published

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Journal:
European journal of immunology
Volume:
29
Issue:
7
Pages:
2156-2166
Publication date:
1999-07-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Source identifiers:
469227

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