Journal article
Absence of co-stimulation and not the intensity of TCR signaling is critical for the induction of T cell unresponsiveness in vivo.
- Abstract:
-
Understanding the mechanisms of T cell activation versus induction of unresponsiveness is of critical importance for the rational modulation of immune responses. Efficient T cell activation is critical for vaccination purposes, while the inhibition of T cell responses is potentially important for the ablation of autoimmune diseases. Modulation of co-stimulation and changing TCR-mediated signaling using altered peptide ligands (APL) have been shown to result in clonal T cell unresponsiveness. ...
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- Publication status:
- Published
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Authors
Bibliographic Details
- Journal:
- European journal of immunology
- Volume:
- 29
- Issue:
- 7
- Pages:
- 2156-2166
- Publication date:
- 1999-07-01
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- Source identifiers:
-
469227
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:469227
- UUID:
-
uuid:525074a1-6925-485f-aa3f-bad674a77b82
- Local pid:
- pubs:469227
- Deposit date:
- 2014-06-17
Terms of use
- Copyright date:
- 1999
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