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Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy.

Abstract:

We have evaluated the effects of anti-TNF-alpha, anti-IL-1, and combined anti-TNF-alpha/anti-CD4 therapy in collagen-induced arthritis. Blockade of TNF-alpha or IL-1 before disease onset delayed, but did not prevent, the induction of arthritis. When treatment was initiated after onset of arthritis, anti-TNF-alpha, anti-IL-1beta, and anti-IL-1R (which blocks IL-1alpha and IL-1beta) were all found to be effective in reducing the severity of arthritis, with anti-IL-1R and anti-IL-1beta showing g...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Marinova-Mutafchieva, L More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
165
Issue:
12
Pages:
7240-7245
Publication date:
2000-12-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:524f98ee-bc73-4d05-903d-54ca2b7b6c90
Source identifiers:
224739
Local pid:
pubs:224739

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