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Journal article

Effect of antiretroviral therapy on plasma concentrations of chloroquine and desethyl-chloroquine

Abstract:
The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor–based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1093/cid/ciy405

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Role:
Author
ORCID:
0000-0002-8529-9317
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Role:
Author
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Johns Hopkins University School of Medicine More from this funder
Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Clinical Infectious Diseases Journal website
Volume:
67
Issue:
10
Pages:
1617–1620
Publication date:
2018-05-02
Acceptance date:
2018-05-02
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Pubs id:
pubs:853451
URN:
uri:52499b58-64b4-42a7-af85-9c23a117e802
UUID:
uuid:52499b58-64b4-42a7-af85-9c23a117e802
Local pid:
pubs:853451
Language:
English

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