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Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.

Abstract:

Chronic hepatitis B virus (HBV) infection afflicts millions worldwide with cirrhosis and liver cancer. HBV e-antigen (HBeAg), a clinical marker for disease severity, is a nonparticulate variant of the protein (core antigen, HBcAg) that forms the building-blocks of capsids. HBeAg is not required for virion production, but is implicated in establishing immune tolerance and chronic infection. Here, we report the crystal structure of HBeAg, which clarifies how the short N-terminal propeptide of H...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2012.10.017

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Journal:
Structure (London, England : 1993)
Volume:
21
Issue:
1
Pages:
133-142
Publication date:
2013-01-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:522a9777-9a05-4b06-a5b0-67102dc206f4
Source identifiers:
367644
Local pid:
pubs:367644

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