- Abstract:
-
Chronic hepatitis B virus (HBV) infection afflicts millions worldwide with cirrhosis and liver cancer. HBV e-antigen (HBeAg), a clinical marker for disease severity, is a nonparticulate variant of the protein (core antigen, HBcAg) that forms the building-blocks of capsids. HBeAg is not required for virion production, but is implicated in establishing immune tolerance and chronic infection. Here, we report the crystal structure of HBeAg, which clarifies how the short N-terminal propeptide of H...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.str.2012.10.017
-
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- Journal:
- Structure (London, England : 1993)
- Volume:
- 21
- Issue:
- 1
- Pages:
- 133-142
- Publication date:
- 2013-01-05
- DOI:
- EISSN:
-
1878-4186
- ISSN:
-
0969-2126
- URN:
-
uuid:522a9777-9a05-4b06-a5b0-67102dc206f4
- Source identifiers:
-
367644
- Local pid:
- pubs:367644
- Copyright date:
- 2013
Journal article
Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.
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