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Journal article

The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.

Abstract:

Aims/hypothesis

The genetic risk of type 1 diabetes has been extensively studied. However, the genetic determinants of age at diagnosis (AAD) of type 1 diabetes remain relatively unexplained. Identification of AAD genes and pathways could provide insight into the earliest events in the disease process.

Methods

Using ImmunoChip data from 15,696 cases, we aimed to identify regions in the genome associated with AAD.

Results

Two regions were convincing...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00125-017-4440-y

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Walker, NM More by this author
Wallace, C More by this author
Bottolo, L More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Publisher:
Springer Publisher's website
Journal:
Diabetologia Journal website
Volume:
61
Issue:
1
Pages:
147–157
Publication date:
2017-10-05
Acceptance date:
2017-07-28
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
Pubs id:
pubs:735447
URN:
uri:521d4ba7-aeeb-46a7-a0a6-2cddf5a54cc2
UUID:
uuid:521d4ba7-aeeb-46a7-a0a6-2cddf5a54cc2
Local pid:
pubs:735447

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