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L-(+)-swainsonine and other pyrrolidine inhibitors of naringinase: Through an enzymic looking glass from D-mannosidase to L-rhamnosidase?

Abstract:
The synthesis and inhibitory properties towards naringinase (L-rhamnosidase) of L-(+)-swainsonine and of a number of more highly oxygenated analogues, and of some monocyclic equivalents, are reported. L-(+)-swainsonine and 1,4,6-trideoxy-1,4-imino-L-mannitol are powerful and specific inhibitors of naringinase.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
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Journal:
TETRAHEDRON LETTERS
Volume:
37
Issue:
47
Pages:
8565-8568
Publication date:
1996-11-18
DOI:
ISSN:
0040-4039
URN:
uuid:5215e061-573b-4aac-b9e9-bb07724d5c38
Source identifiers:
45381
Local pid:
pubs:45381

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