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PPARγ2 gene Pro12Ala and PPARα gene Leu162Val single nucleotide polymorphisms interact with dietary intake of fat in determination of plasma lipid concentrations.

Abstract:

BACKGROUND/AIMS: The peroxisome proliferator-activated receptors (PPARs) are transcriptional regulators of lipid metabolism, activated by unsaturated fatty acids. We investigated independent and interactive effects of PPARγ2 gene PPARG Pro12Ala (rs1801282) andPPARαgene PPARA Leu162Val (rs1800206) genotypes with dietary intake of fatty acids on concentrations of plasma lipids in subjects of whom 47.5% had metabolic syndrome. METHODS: The RISCK study is a parallel design, randomised controlled ...

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Publication status:
Published

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Publisher copy:
10.1159/000336362

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Journal:
Journal of nutrigenetics and nutrigenomics
Volume:
4
Issue:
6
Pages:
354-366
Publication date:
2011-01-01
DOI:
EISSN:
1661-6758
ISSN:
1661-6499
Source identifiers:
429965

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