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Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9.

Abstract:

OBJECTIVE Mesenchymal stem cells (MSCs) are known to be capable of suppressing immune responses, but the molecular mechanisms involved and the therapeutic potential of MSCs remain to be clarified.

RESEARCH DESIGN AND METHODS We investigated the molecular mechanisms underlying the immunosuppressive effects of MSCs in vitro and in vivo.

RESULTS Our results demonstrate that matrix metalloproteinases (MMPs) secreted by MSCs, in p...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.2337/db09-0317

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
58
Issue:
8
Pages:
1797-1806
Publication date:
2009-08-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:51fccbdf-09cc-4c63-b702-f9f491599995
Source identifiers:
130927
Local pid:
pubs:130927

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