Journal article
Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9.
- Abstract:
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OBJECTIVE Mesenchymal stem cells (MSCs) are known to be capable of suppressing immune responses, but the molecular mechanisms involved and the therapeutic potential of MSCs remain to be clarified.
RESEARCH DESIGN AND METHODS We investigated the molecular mechanisms underlying the immunosuppressive effects of MSCs in vitro and in vivo.
RESULTS Our results demonstrate that matrix metalloproteinases (MMPs) secreted by MSCs, in p...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 604.0KB, Terms of use)
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- Publisher copy:
- 10.2337/db09-0317
Authors
Funding
Bibliographic Details
- Publisher:
- American Diabetes Association
- Journal:
- Diabetes More from this journal
- Volume:
- 58
- Issue:
- 8
- Pages:
- 1797-1806
- Publication date:
- 2009-08-01
- DOI:
- EISSN:
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1939-327X
- ISSN:
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0012-1797
Item Description
- Language:
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English
- Keywords:
-
- UUID:
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uuid:51fccbdf-09cc-4c63-b702-f9f491599995
- Local pid:
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pubs:130927
- Source identifiers:
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130927
- Deposit date:
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2012-12-19
Terms of use
- Copyright holder:
- American Diabetes Association
- Copyright date:
- 2009
- Notes:
-
© 2009 by the American Diabetes Association. Readers may use this article as
long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details
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