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The role of the Na+/Ca2+ exchangers in Ca2+ dynamics in ventricular myocytes.

Abstract:

The role of the Na+/Ca2+ exchanger (NCX) as the main pathway for Ca2+ extrusion from ventricular myocytes is well established. However, both the role of the Ca2+ entry mode of NCX in regulating local Ca2+ dynamics and the role of the Ca2+ exit mode during the majority of the physiological action potential (AP) are subjects of controversy. The functional significance of NCXs location in T-tubules and potential co-localization with ryanodine receptors was examined using a local Ca2+ control mod...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Progress in biophysics and molecular biology
Volume:
96
Issue:
1-3
Pages:
377-398
Publication date:
2008-01-01
DOI:
EISSN:
1873-1732
ISSN:
0079-6107
Source identifiers:
237480
Language:
English
Keywords:
Pubs id:
pubs:237480
UUID:
uuid:51fad05d-d425-4407-9391-28bf7cd5a48b
Local pid:
pubs:237480
Deposit date:
2013-11-16

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