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A role for solvents in the toxicity of agricultural organophosphorus pesticides.

Abstract:

Organophosphorus (OP) insecticide self-poisoning is responsible for about one-quarter of global suicides. Treatment focuses on the fact that OP compounds inhibit acetylcholinesterase (AChE); however, AChE-reactivating drugs do not benefit poisoned humans. We therefore studied the role of solvent coformulants in OP toxicity in a novel minipig model of agricultural OP poisoning. Gottingen minipigs were orally poisoned with clinically relevant doses of agricultural emulsifiable concentrate (EC) ...

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Publication status:
Published

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Publisher copy:
10.1016/j.tox.2012.02.005

Authors


Eddleston, M More by this author
Street, JM More by this author
Thompson, A More by this author
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Journal:
Toxicology
Volume:
294
Issue:
2-3
Pages:
94-103
Publication date:
2012-04-05
DOI:
EISSN:
1879-3185
ISSN:
0300-483X
URN:
uuid:51e46f5b-7e5b-4611-a997-a2ba3d2446e2
Source identifiers:
320803
Local pid:
pubs:320803

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