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The immune response to melanoma is limited by thymic selection of self-antigens.

Abstract:

The expression of melanoma-associated antigens (MAA) being limited to normal melanocytes and melanomas, MAAs are ideal targets for immunotherapy and melanoma vaccines. As MAAs are derived from self, immune responses to these may be limited by thymic tolerance. The extent to which self-tolerance prevents efficient immune responses to MAAs remains unknown. The autoimmune regulator (AIRE) controls the expression of tissue-specific self-antigens in thymic epithelial cells (TECs). The level of ant...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0035005

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
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Author
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Medical Research Council More from this funder
Andrew McMichael fund More from this funder
Biotechnology and Biological Research Council More from this funder
Biomedical Research Centre Oxford More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
7
Issue:
4
Pages:
Article: e35005
Publication date:
2012-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:51c55e80-ef1d-4992-9cd6-b68fad99eba4
Source identifiers:
325183
Local pid:
pubs:325183

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