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Comparison of 5-aminosalicylic acid and N-acetylaminosalicylic acid uptake by the isolated human colonic epithelial cell.

Abstract:

Isolated human colonic epithelial cell suspensions were incubated with either 0.1 mM 5-aminosalicylic acid (5-ASA) or 0.1 mM acetylaminosalicylic acid (Ac-ASA) for up to two hours. Intra- and extracellular 5-ASA and Ac-ASA were measured by high performance liquid chromatography. Mean 5-ASA uptake in one hour was 160.5 nmol/g dry weight, compared with an Ac-ASA uptake of only 5.75 nmol/g dry weight. No unchanged 5-ASA was detected inside the cell. Repeated washing had no effect on the intracel...

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Publication status:
Published

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Publisher copy:
10.1136/gut.33.10.1343

Authors


Ireland, A More by this author
Priddle, JD More by this author
Jewell, DP More by this author
Publisher:
BMJ Publishing Group
Journal:
Gut
Volume:
33
Issue:
10
Pages:
1343-1347
Publication date:
1992-10-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:51babe50-f36b-4f96-891e-cbe181a15bc2
Source identifiers:
135417
Local pid:
pubs:135417

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