Functional diversity of macrophages in vascular biology and disease

Journal article

Atherosclerosis is a multifactorial chronic inflammatory disease and is largely responsible for cardiovascular disease, the most common cause of global mortality. The hallmark of atherogenesis is immune activation following lipid accumulation in the arterial wall. In particular, macrophages play a non-redundant role in both the progression and regression of inflammation in the atherosclerotic lesion. Macrophages are remarkably heterogeneous phagocytes that perform versatile functions in healt...

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Authors: Park, I; Kassiteridi, C; Monaco, C

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Vascular Pharmacology
• Volume: 99
• Pages: 13-22
• Publication date: 2017-10-24
• Acceptance date: 2017-10-19
• DOI: 10.1016/j.vph.2017.10.005
• EISSN: 1879-3649
• ISSN: 1537-1891
• Pmid: 29074468
• Language: English
• Keywords: Anti-Inflammatory Agents; Arteries; Inflammation Mediators; Animals; Transcription Factors; Inflammation; Phenotype; Macrophages; Humans; Cellular Microenvironment; Atherosclerosis