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Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment

Abstract:

Is it possible to prevent atrophy of key brain regions related to cognitive decline and Alzheimer’s disease (AD)? One approach is to modify nongenetic risk factors, for instance by lowering elevated plasma homocysteine using B vitamins. In an initial, randomized controlled study on elderly subjects with increased dementia risk (mild cognitive impairment according to 2004 Petersen criteria), we showed that high-dose B-vitamin treatment (folic acid 0.8 mg, vitamin B6 20 mg, vitamin B12 0.5 mg) ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1301816110

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Department:
Oxford, MSD, Clinical Neurosciences
De Jager, CA More by this author
Nichols, TE More by this author
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of the United States of America Journal website
Volume:
110
Issue:
23
Pages:
9523-9528
Publication date:
2013-06-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:401176
URN:
uri:519f3aea-761a-487d-9e34-b41bf6aa4a8d
UUID:
uuid:519f3aea-761a-487d-9e34-b41bf6aa4a8d
Local pid:
pubs:401176
Language:
English
Keywords:

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