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Three genes, IgtF, Iic2C and IpsA, have a primary role in determining the pattern of oligosaccharide extension from the inner core of Haemophilus influenzae LPS

Abstract:

Lipopolysaccharide (LPS) is a virulence determinant of Haemophilus influenzae and exhibits substantial heterogeneity in structure within and between strains. Key factors contributing to this heterogeneity are the genes required to add the first glycose to each of the three heptose residues of the LPS inner core. In each case this addition can facilitate further oligosaccharide extension. lgtF is invariably present in strains and the product has a function in adding the glucose to the first he...

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Publication status:
Published

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Publisher copy:
10.1099/mic.0.26912-0

Authors


Deadman, ME More by this author
Makepeace, K More by this author
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Journal:
MICROBIOLOGY-SGM
Volume:
150
Issue:
7
Pages:
2089-2097
Publication date:
2004-07-05
DOI:
EISSN:
1465-2080
ISSN:
1350-0872
URN:
uuid:519b0947-449c-439b-9108-1a493281d953
Source identifiers:
115608
Local pid:
pubs:115608
Language:
English

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