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Journal article

Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains

Abstract:

The promoters of mammalian genes are commonly regulated by multiple distal enhancers, which physically interact within discrete chromatin domains. How such domains form and how the regulatory elements within them interact in single cells is not understood. To address this we developed Tri-C, a new chromosome conformation capture (3C) approach, to characterize concurrent chromatin interactions at individual alleles. Analysis by Tri-C identifies heterogeneous patterns of single-allele interacti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41588-018-0253-2

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Inst of Molecular Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Inst of Molecular Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Inst of Molecular Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Inst of Molecular Medicine
ORCID:
0000-0003-4353-3854
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
MSD Doctoral Training Centre
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Funding agency for:
Oudelaar, AM
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Funding agency for:
Hughes, JR
Howard Hughes Medical Institute More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
50
Pages:
1744–1751
Publication date:
2018-10-29
Acceptance date:
2018-09-07
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:935894
URN:
uri:51921701-5266-44b6-beea-d6139dfaf3d0
UUID:
uuid:51921701-5266-44b6-beea-d6139dfaf3d0
Local pid:
pubs:935894
Language:
English

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