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Bacteriophage therapy and the mutant selection window.

Abstract:

We use kinetic models to investigate how to design antimicrobial phage therapies to minimize emergence of resistant bacteria. We do this by modifying the "mutant selection window" hypothesis in a way that accounts for the ongoing self-replication of the phage. We show that components of combination phage therapies need to be appropriately matched if treatment is to avoid the emergence of resistant bacteria. Matching of components is more easily achieved when phage dosages are high enough that...

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Publication status:
Published

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Publisher copy:
10.1128/aac.00574-08

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Institution:
University of Oxford
Department:
Oxford, MSD, Unassigned
Journal:
Antimicrobial agents and chemotherapy
Volume:
52
Issue:
12
Pages:
4344-4350
Publication date:
2008-12-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:519014e0-fd99-4b2b-ada4-7e15f8e7611f
Source identifiers:
255957
Local pid:
pubs:255957

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