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Journal article

Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.

Abstract:

Cell surface proteins major histocompatibility complex (MHC) class I-related chain A (MICA) and UL16-binding proteins (ULBP) 1, 2, and 3 are up-regulated upon infection or tumor transformation and can activate human natural killer (NK) cells. Patches of cross-linked raft resident ganglioside GM1 colocalized with ULBP1, 2, 3, or MICA, but not CD45. Thus, ULBPs and MICA are expressed in lipid rafts at the cell surface. Western blotting revealed that glycosylphosphatidylinositol (GPI)-anchored U...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20032194

Authors


Collinson, LM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
The Journal of experimental medicine
Volume:
199
Issue:
7
Pages:
1005-1010
Publication date:
2004-04-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:518e7f8b-8bad-4374-a3f2-7764065025ff
Source identifiers:
503935
Local pid:
pubs:503935

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