Effect of atrial natriuretic peptide on cellular element concentrations in rat proximal tubules: evidence for inhibition of the sodium pump.

Journal article

1. In order to further define the action of atrial natriuretic peptide (ANP) on proximal tubular (PT) transport, combined clearance and electron microprobe X-ray (EMPX) experiments were performed on five male Wistar rats infused with ANP (0.16 nmol/kg per h) and nine control animals. 2. Electron microprobe X-ray analysis of PT cell electrolytes (mmol/kg wet weight) revealed a similar [Na]i in both the control and ANP treated groups (16.4 +/- 0.4 vs 16.5 +/- 0.4; P = 0.894). [Cl]i was lower in...

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Authors: Reddy, S; Györy, A; Dyne, M; Salipan-Moore, N; Pollock, C

• Publication status: Published
• Journal: Clinical and experimental pharmacology and physiology
• Volume: 21
• Issue: 10
• Pages: 775-780
• Publication date: 1994-10-01
• DOI: 10.1111/j.1440-1681.1994.tb02445.x
• EISSN: 1440-1681
• ISSN: 0305-1870
• Language: English
• Keywords: Rats, Wistar; Sodium-Hydrogen Antiporter; Potassium; Atrial Natriuretic Factor; Osmolar Concentration; Electron Probe Microanalysis; Electrolytes; Kidney Tubules, Proximal; Male; Animals; Rats; Glomerular Filtration Rate; Sodium-Potassium-Exchanging ATPase