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Membrane compartmentalization reduces the mobility of lipids and proteins within a model plasma membrane

Abstract:

The cytoskeleton underlying cell membranes may influence the dynamic organization of proteins and lipids within the bilayer by immobilizing certain transmembrane (TM) proteins and forming corrals within the membrane. Here we present coarse-grained resolution simulations of a biologically realistic membrane model of asymmetrically organized lipids and TM proteins. We determine the effects of a model of cytoskeletal immobilization of selected membrane proteins using long timescale coarse-graine...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.jpcb.6b05846

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Institution:
University of Oxford
Oxford college:
Christ Church
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Alfred Benzon Foundation More from this funder
Engineering and Physical Sciences Research Council More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
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Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Physical Chemistry Part B Journal website
Volume:
120
Issue:
34
Pages:
8873–8881
Publication date:
2016-08-01
Acceptance date:
2016-08-02
DOI:
EISSN:
1520-5207
ISSN:
1520-6106
Source identifiers:
637270
Keywords:
Pubs id:
pubs:637270
UUID:
uuid:51886719-a4bc-428b-85e2-101f017ada2e
Local pid:
pubs:637270
Deposit date:
2016-08-03

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