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Dysregulated hematopoietic stem and progenitor cell activity promotes interleukin-23-driven chronic intestinal inflammation.

Abstract:

In interleukin-23 (IL-23)-dependent colitis, there is excessive accumulation of short-lived neutrophils and inflammatory monocytes in the intestine. It is unknown whether this reflects changes in mature cell populations or whether the IL-23-driven colitogenic T cell program regulates upstream hematopoietic stem and progenitor cells (HSPC). Here we have shown dysregulation of hematopoiesis in colitis mediated by inflammatory cytokines. First, there was an interferon-gamma-dependent accumulatio...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
McKenzie, BS More by this author
Schiering, C More by this author
Volume:
37
Issue:
6
Pages:
1116-1129
Publication date:
2012-12-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
URN:
uuid:5183c98d-7b64-46ae-86c4-dfab1ee4b58a
Source identifiers:
356436
Local pid:
pubs:356436

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