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Regulation of neuronal high-voltage activated CaV2 Ca2+ channels by the small GTPase RhoA

Abstract:

High-Voltage-Activated (HVA) Ca(2+) channels are known regulators of synapse formation and transmission and play fundamental roles in neuronal pathophysiology. Small GTPases of Rho and RGK families, via their action on both cytoskeleton and Ca(2+) channels are key molecules for these processes. While the effects of RGK GTPases on neuronal HVA Ca(2+) channels have been widely studied, the effects of RhoA on the HVA channels remains however elusive. Using heterologous expression in Xenopus laev...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.neuropharm.2015.05.019

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Association Française contre les Myopathies More from this funder
Agence nationale de la recherche More from this funder
Institut national de la santé et de la recherche médicale More from this funder
Centre national de la recherche scientifique More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Neuropharmacology Journal website
Volume:
97
Pages:
201-209
Publication date:
2015-06-01
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
Source identifiers:
526455
Language:
English
Keywords:
Pubs id:
pubs:526455
UUID:
uuid:517be00a-b83d-45d6-b0e4-fba89889535e
Local pid:
pubs:526455
Deposit date:
2015-11-01

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