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Regulation of neuronal high-voltage activated CaV2 Ca2+ channels by the small GTPase RhoA

Abstract:

High-Voltage-Activated (HVA) Ca(2+) channels are known regulators of synapse formation and transmission and play fundamental roles in neuronal pathophysiology. Small GTPases of Rho and RGK families, via their action on both cytoskeleton and Ca(2+) channels are key molecules for these processes. While the effects of RGK GTPases on neuronal HVA Ca(2+) channels have been widely studied, the effects of RhoA on the HVA channels remains however elusive. Using heterologous expression in Xenopus laev...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.neuropharm.2015.05.019

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Centre national de la recherche scientifique More from this funder
Institut national de la santé et de la recherche médicale More from this funder
Agence nationale de la recherche More from this funder
Association Française contre les Myopathies More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Neuropharmacology Journal website
Volume:
97
Pages:
201-209
Publication date:
2015-06-01
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
URN:
uuid:517be00a-b83d-45d6-b0e4-fba89889535e
Source identifiers:
526455
Local pid:
pubs:526455

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