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Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

Abstract:
Background Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. Methods We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/S0140-6736(18)30134-X

Authors


Kaptoge, S More by this author
Butterworth, AS More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics & Gynaecology
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM Experimental Medicine
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Grant:
G0800270 and MR/L003120/1
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Grant:
SP/09/002 and RG/08/014 and RG13/13/30194
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Grant:
NIHR Cambridge Biomedical Research Centre
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Grant:
Framework 7 (through the EPIC-CVD award; HEALTH-F2-2012-279233)
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Grant:
Advanced Investigator Award to J Danesh; 268834
Publisher:
Elsevier Publisher's website
Journal:
Lancet Journal website
Volume:
391
Issue:
10129
Pages:
1513-1523
Publication date:
2018-04-12
Acceptance date:
2018-02-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Pubs id:
pubs:823044
URN:
uri:517a2804-7033-474f-a99c-f4688fa044f4
UUID:
uuid:517a2804-7033-474f-a99c-f4688fa044f4
Local pid:
pubs:823044

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