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Journal article

MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion.

Abstract:

Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s. We show that MHCII-expressing ILC2s interact with antigen- specific T cells to instigate a dialog in which IL-2 production from T cells promotes ILC2 proliferation and IL-13 production. Deletion ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.immuni.2014.06.016

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
Role:
Author
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American Asthma Foundation More from this funder
Medical Research Council More from this funder
Agency for Science Technology and Research More from this funder
Science Foundation Ireland and National Children’s Research Centre More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Immunity Journal website
Volume:
41
Issue:
2
Pages:
283-295
Publication date:
2016-04-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
URN:
uuid:51751b7d-37be-4878-a982-33c43335e468
Source identifiers:
479851
Local pid:
pubs:479851
Paper number:
2

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