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Voltage-dependent insertion of alamethicin at phospholipid/water and octane/water interfaces.

Abstract:

Understanding the binding and insertion of peptides in lipid bilayers is a prerequisite for understanding phenomena such as antimicrobial activity and membrane-protein folding. We describe molecular dynamics simulations of the antimicrobial peptide alamethicin in lipid/water and octane/water environments, taking into account an external electric field to mimic the membrane potential. At cis-positive potentials, alamethicin does not insert into a phospholipid bilayer in 10 ns of simulation, du...

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Publication status:
Published

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Authors


Tieleman, DP More by this author
Berendsen, HJ More by this author
Sansom, MS More by this author
Journal:
Biophysical journal
Volume:
80
Issue:
1
Pages:
331-346
Publication date:
2001-01-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:517446ae-afc7-4daf-9a78-60d170d56414
Source identifiers:
100817
Local pid:
pubs:100817

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