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Journal article

Structural basis of mechanochemical coupling in a hexameric molecular motor.

Abstract:

The P4 protein of bacteriophage phi12 is a hexameric molecular motor closely related to superfamily 4 helicases. P4 converts chemical energy from ATP hydrolysis into mechanical work, to translocate single-stranded RNA into a viral capsid. The molecular basis of mechanochemical coupling, i.e. how small approximately 1 A changes in the ATP-binding site are amplified into nanometer scale motion along the nucleic acid, is not understood at the atomic level. Here we study in atomic detail the mech...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m706366200

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Journal:
The Journal of biological chemistry
Volume:
283
Issue:
6
Pages:
3607-3617
Publication date:
2008-02-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:516ff351-7f3e-4072-811c-ef983e5b572b
Source identifiers:
4603
Local pid:
pubs:4603

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