Muscle pathology, dystrophin expression and X-inactivation patterns were studied in the muscle of five asymptomatic females heterozygous for deletions in the dystrophin gene (non-manifesting carriers) and five symptomatic carriers (manifesting carriers). Muscle from the non-manifesting carriers showed an increase in the population of centrally nucleated fibres (9.0 +/- 2.8%; controls, 1.4 +/- 0.3%), frequent fibers with abnormally interrupted dystrophin staining (38 +/- 5%), and, in sections ...Expand abstract
- Publisher copy:
- Copyright date:
Muscle X-inactivation patterns and dystrophin expression in Duchenne muscular dystrophy carriers.
If you are the owner of this record, you can report an update to it here: Report update to this record