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Identification of differentially expressed proteins from Burkholderia pseudomallei isolated during primary and relapsing melioidosis.

Abstract:

Burkholderia pseudomallei causes septicemic melioidosis with a high rate of relapse, however microbial determinants of relapse are unknown. Proteins were analyzed from sequential B. pseudomallei isolates from primary and relapsing melioidosis. Analysis by isotope tagging for relative and absolute quantitation revealed that factors required for nitric oxide detoxification (HmpA) and necessary for anaerobic growth (ArcA, ArcC and ArcB) were highly expressed in the relapse isolate. Two-dimension...

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Publication status:
Published

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Authors


Velapatiño, B More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Peacock, SJ More by this author
Speert, DP More by this author
Journal:
Microbes and infection / Institut Pasteur
Volume:
14
Issue:
4
Pages:
335-340
Publication date:
2012-04-05
DOI:
EISSN:
1769-714X
ISSN:
1286-4579
URN:
uuid:5168abcb-5b73-4071-b114-4a14da7cb8a7
Source identifiers:
221330
Local pid:
pubs:221330

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