- Abstract:
-
BACKGROUND: It has been shown that increases in intraluminal flow elicit dilation in venules, but the mediation of response is not yet clarified. We hypothesized that - in addition to nitric oxide (NO) and dilator prostaglandins (PGI(2)/ PGE(2)) - thromboxane A(2) (TxA(2)) contributes to the mediation of flow-induced responses of venules. METHODS AND RESULTS: Isolated rat gracilis muscle venules (259 +/- 11 microm at 10 mm Hg) dilated as a function of intraluminal flow, which was augmented i...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1159/000194270
-
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- Journal:
- Journal of vascular research
- Volume:
- 46
- Issue:
- 5
- Pages:
- 397-405
- Publication date:
- 2009
- DOI:
- EISSN:
-
1423-0135
- ISSN:
-
1018-1172
- URN:
-
uuid:5166c5b0-03ce-49b9-b5ed-0239cd5ec626
- Source identifiers:
-
164570
- Local pid:
- pubs:164570
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Thromboxane A(2) contributes to the mediation of flow-induced responses of skeletal muscle venules: role of cyclooxygenases 1 and 2.
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