Journal article icon

Journal article

Thromboxane A(2) contributes to the mediation of flow-induced responses of skeletal muscle venules: role of cyclooxygenases 1 and 2.

Abstract:

BACKGROUND: It has been shown that increases in intraluminal flow elicit dilation in venules, but the mediation of response is not yet clarified. We hypothesized that - in addition to nitric oxide (NO) and dilator prostaglandins (PGI(2)/ PGE(2)) - thromboxane A(2) (TxA(2)) contributes to the mediation of flow-induced responses of venules. METHODS AND RESULTS: Isolated rat gracilis muscle venules (259 +/- 11 microm at 10 mm Hg) dilated as a function of intraluminal flow, which was augmented i...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1159/000194270

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Journal of vascular research
Volume:
46
Issue:
5
Pages:
397-405
Publication date:
2009
DOI:
EISSN:
1423-0135
ISSN:
1018-1172
URN:
uuid:5166c5b0-03ce-49b9-b5ed-0239cd5ec626
Source identifiers:
164570
Local pid:
pubs:164570

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP