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Structures of DPAGT1 explain glycosylation disease mechanisms and advance TB antibiotic design

Abstract:

Protein N-glycosylation is a widespread post-translational modification. The first committed step in this process is catalysed by dolichyl-phosphate N-acetylglucosamine-phosphotransferase DPAGT1 (GPT/E.C. 2.7.8.15). Missense DPAGT1 variants cause congenital myasthenic syndrome and disorders of glycosylation. In addition, naturally-occurring bactericidal nucleoside analogues such as tunicamycin are toxic to eukaryotes due to DPAGT1 inhibition, preventing their clinical use. Our structures of D...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.cell.2018.10.037

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Structural Genomics Consortium
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Structural Genomics Consortium
Cochrane, SA More by this author
Hamedzadeh, S More by this author
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Funding agency for:
Cochrane, SA
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Funding agency for:
Mukhopadhyay, SMM
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Funding agency for:
Robinson, CV
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Publisher:
Elsevier Publisher's website
Journal:
Cell Journal website
Volume:
175
Issue:
4
Pages:
1045-1058.e16
Publication date:
2018-11-01
Acceptance date:
2018-10-15
DOI:
ISSN:
0092-8674 and 1097-4172
Pubs id:
pubs:938203
URN:
uri:515d9416-1e72-4e91-87e4-39eb4f426368
UUID:
uuid:515d9416-1e72-4e91-87e4-39eb4f426368
Local pid:
pubs:938203

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