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Systemic administration of fibroblast growth factor-2 (FGF2) reduces BACE1 expression and amyloid pathology in APP23 mice

Abstract:

There is an emerging evidence that growth factors may have a potential beneficial use in the treatment of Alzheimer's disease (AD) because of their neuroprotective properties and effects on neuronal proliferation. Basic fibroblast growth factor or fibroblast growth factor-2 (FGF2) is an anti-inflammatory, angiogenic, and neurotrophic factor that is expressed in many cell types, including neurons and glial cells. Here, we explored whether subcutaneous administration of FGF2 could have therapeu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Department:
Oxford, MSD, NDM, Target Discovery Institute
Mirzaei, N More by this author
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Johnson & Johnson More from this funder
Imperial innovations More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Neurobiology of Aging Journal website
Volume:
36
Issue:
2
Pages:
821-831
Publication date:
2014-10-13
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
Pubs id:
pubs:614438
URN:
uri:514e5189-0552-45e8-8e01-a44c5f6fe800
UUID:
uuid:514e5189-0552-45e8-8e01-a44c5f6fe800
Local pid:
pubs:614438

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