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Optimal cutoff and accuracy of an IgM enzyme-Linked immunosorbent assay for diagnosis of acute scrub typhus in northern Thailand: an alternative reference method to the IgM immunofluorescence assay

Abstract:

The enzyme-linked immunosorbent assay (ELISA) has been proposed as an alternative serologic diagnostic test to the indirect immunofluorescence assay (IFA) for scrub typhus. Here, we systematically determine the optimal sample dilution and cutoff optical density (OD) and estimate the accuracy of IgM ELISA using Bayesian latent class models (LCMs). Data from 135 patients with undifferentiated fever were reevaluated using Bayesian LCMs. Every patient was evaluated for the presence of an eschar a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/JCM.02744-15

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
Tanganuchitcharnchai, A More by this author
Jintaworn, S More by this author
Kantipong, P More by this author
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Funding agency for:
Lim, C
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Funding agency for:
Limmathurotsakul, D
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Funding agency for:
Day, NP
Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of clinical microbiology Journal website
Volume:
54
Issue:
6
Pages:
1472-1478
Publication date:
2016-06-05
DOI:
EISSN:
1098-660X
ISSN:
0095-1137
URN:
uuid:5145d05a-21be-4d1f-bed2-f56f84479ddc
Source identifiers:
611893
Local pid:
pubs:611893
Language:
English

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