Parental non-inherited HLA resistance alleles do not confer protection against multiple sclerosis.

Journal article

Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. HLA-DRB1*14 and DRB1*11 bearing haplotypes protect against MS and DRB1*01 and DRB1*10 interact with DRB1*15 to reduce risk of the disease. Recent work in other autoimmune diseases such as rheumatoid arthritis has suggested that maternal non-transmitted protective alleles can also confer disease resistance. In this investigation of 7093 indivi...

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Authors: Ramagopalan, S; Dyment, D; Herrera, B; DeLuca, G; Lincoln, MR

• Publication status: Published
• Journal: Journal of neuroimmunology
• Volume: 196
• Issue: 1-2
• Pages: 170-172
• Publication date: 2008-05-01
• DOI: 10.1016/j.jneuroim.2008.03.005
• EISSN: 1872-8421
• ISSN: 0165-5728
• Language: English
• Keywords: Humans; Alleles; Female; Inheritance Patterns; Genotype; Multiple Sclerosis; Family Health; HLA-DR Antigens; Parents; Male